What improvements in the human body will allow it to withstand critically low or high pressure?
My question: What is it that needs to be improved or added to the human body so that it can withstand critically (fatally) low and high (if, my genetically modified person is underwater or a very dense atmosphere, like Venus) pressure for a person? Relative to survival at low atmospheric pressure:
At these low pressures, adaptation is not possible. The key is your observation that "with water boiling at 25-30*C". Since normal body temperature is 37 C, while blood does not boil, saliva and all the fluid in the lungs which lubricate the alveoli will instantly boil off. Not to mention your eyes losing all lubrication from tears, which will shortly produce blindness due to friction with the eyelids.
This is an example of the Armstrong Limit, and this limits minimum pressure to just about 10% of sea level, even with pure oxygen.
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