A drug that allows people to survive on less food

In this near-future setting, biotechnology is slightly more advanced than our own. Genetic engineering is cheap as well, but due to an ecological disaster the environment just doesn't have enough calories to go around.

What I am looking for is a known chemical, drug, or (if necessary) a SPECIFIC genetic mutation (as in, a particular gene that has been identified by modern science) that allows people to survive on fewer calories. This mechanism may have side effects.

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A drug that allows people to survive on less food

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