Could sentient mitochondria evolve?

Hideaki Sena's cult classic novel, Parasite Evil and it's video game sequels revolve around the premise of mitochondria gaining sentience and usurping mankind after aeons upon aeons of multicellular organisms evolving, owning back to their origins as separate prokaryotic organisms. Somehow, they also gained the ability to access the thoughts and memories of a host, implanting suggestions and even communicating or alter cellular structure and physiology.

How could sentient mitochondria logically evolve and what are some critical environmental or sociological factors that might come into play and dramatically impact their evolutionary process?

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Could sentient mitochondria evolve?

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