How long would it take for segregate human populations to speciate to a point where they could not interbreed?

Coming from an earlier asked question, I was wondering how long it would take (potentially a range) for two human populations that are separated from each other to speciate enough that they would no longer be able to interbreed.

Far in the future, humans have developed the technology to commit to interstellar travel and colonize new planets. Different groups set off to new parts of the universe, and can sometimes get lost/cut off from the rest of the original group of human civilization that they derived from. At what point would speciation prevent one segregate popoulation be unable to breed with another?

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How long would it take for segregate human populations to speciate to a point where they could not interbreed?

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