Could a mass made up of certain elements or compounds "disrupt" a star?

Inspired by this interesting question-- let's say that the universe was just really, really out to get a particular star, such as our sun. Is there a perfect cocktail where a mass significantly smaller than a star could cause the star to behave strangely after impact?

I'm not just referring to a massive pile of salts crashing into the sun and making a pretty multi-colored burst around the impact, but something that would disrupt the underlying nuclear processes of the star in a way that would be observable from Earth.

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Could a mass made up of certain elements or compounds "disrupt" a star?

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