How big and numerous do ticks needs to be to threaten human life?

A world has grassy plains infested with larger-than-normal (perhaps even giant) blood-sucking ticks. Ignoring their main diet for the time being: They should be dangerous enough to threaten humans specifically by blood loss (not just by disease/immune reaction).

How many ticks - and of what size - would need to attach to a person so that blood loss would start to be a real issue?

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How big and numerous do ticks needs to be to threaten human life?

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