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A deadly disease, 95% of the population dead, suppresses or alters memory in unpredictable ways

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Whilst not strictly relevant to this question, the questions and answers may interest the curious: this is the 4th in a series of question here - 1, 2, 3.

  • My population (in excess of 500,000) undergoes a huge dieback event, almost extinction. Narrative necessity (possibly) dictates this.

  • I've run through the possibilities and disease is the only feasible cause in this case. Other suggestions that fit with the requirements, are fine though.

Is there a disease or potential treatment for a disease which could result in (large-scale death and/or) memory suppression or memory alteration?

Caveats:

  • The memory loss may only need to last a matter of months, societal collapse and grief may take care of the rest.

  • Disease treatment resulting in additional memory loss could be acceptable here.

  • Setting: In term of medicine, equivalent to England in the dark ages, ie people were uneducated and prepared to try anything.

  • My understanding is that some psychotherapeutic treatments have been accused of creating false memories. There is no modern psychotherapy in this world, answers should take into account social behaviour of a non-scientific society which has no single organised advanced medical provision.

  • There is trade with other areas, many plants/medicines may be touted by "snake oil" salesmen, not to mention tics, parasites, reptiles etc maybe hitching a ride.

  • Any plant/animal toxin may be taken into account and a mixture of those would be fine if it has the desired effects.

  • No asteroids, environmental collapse, nearby nova events, sun eruptions or geological events will be considered.

The Key: Whilst certain memories may be available to the population with effort of recall, these memories will no longer seem important or influence their behaviour.

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