Physiological effects of huge anime eyes

Anime, Disney, and many, many other works feature human characters with ridiculously oversized eyes. This is usually just a stylistic choice, and had little to no effect on anything in-story or in-universe. What if it did have an effect?

Say that a real-world human was given eyes of the same proportion as the stylized ones you see in anime, Disney, etc: What would the physiological effects be? What would be gained, and what would be lost?

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Physiological effects of huge anime eyes

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