How Could a Disease that Lowers the Intelligence of Humans to Non-Sapient Levels Exist?

I am curious if there is a way for a disease to negatively effect the intelligence of humans;reducing them to non-sapient ferals in the end. I am curious what such a disease would need to do to effectively achieve this and how it could originate.

The disease,parasite,etc can be naturally occurring or artificial for the purposes of answers. I simply wish to know if and how this can happen.

Edit: Keep in mind that the use of feral in this case is the adjective use. These humans act like wild animals, similar to chimpanzees or smart dogs in remaining intellect. They are no longer who they once were. Effectively becoming a wild animal in human skin.

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How Could a Disease that Lowers the Intelligence of Humans to Non-Sapient Levels Exist?

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