What injury would be of little consequence to a biped but terrible for a quadruped?

Let's imagine a group of people who can turn from human to wolf at will. Wolves are quadrupeds, and humans are biped, so I guess their weight is differently shared in their body, notably when they walk.

Assuming that, if one such person receives a wound in one form, it is placed in the equivalent of that place on the body of the other form, is there a place on the body that, if wounded, would prevent practical use of the wolf form while having little to no consequence to the human form?

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What injury would be of little consequence to a biped but terrible for a quadruped?

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