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Is intraspecies genetic incompatibility possible?

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I'm creating a humanoid species, roughly based on humans. The difference is that not every opposite sex couple of fertile age could produce offspring.

The premise of my story is based of some men being incompatible with some women. And I mean genetically, if they mate they won't be able to produce children.

Is this possible?

And is there something similar in the nature, it doesn't have to be in humans.

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This post was sourced from https://worldbuilding.stackexchange.com/q/132195. It is licensed under CC BY-SA 4.0.

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