How would a human have to be gene-geneered to thrive in a zero-g environment?

I'm trying to create a massive contained zero-g environment that can sustain many life-forms including humans. The research that I'm doing doesn't make it look good. Seems like we just need gravity.

But say we could build a human to survive in zero-g without the problems astronauts have encountered so far, what changes would have to be made? Or maybe another way to approach this question is what would make a human who can survive in zero-g different from us, who cant?

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How would a human have to be gene-geneered to thrive in a zero-g environment?

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