Reasons for pregnancy to be difficult in long-term space travel

I am looking for medically viable reasons why we might discover it to be more difficult than expected to bring pregnancies to term in space. This is for a society based approximately 75 years in the future that was forced into long-term space travel with limited time for preparation, which is to say technology is advanced but not perfected.

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Reasons for pregnancy to be difficult in long-term space travel

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