How to modify DNA without using computers?

I would like for a civilization to be very good at bio-engineering, but I do not know how they would be able to modify DNA to suit their purposes, with greater things than breeding can bring. For example, giving natural armor to certain animals so they could take bullets.

Or more important to this species, they are interested in giving an animal, which spits acid, armor and turning it into a gun of sorts. The animal has not developed armor, and has no DNA coding for armor to really work off of. Any way to accomplish this?

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How to modify DNA without using computers?

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