Preventing inter-species breeding in humanoids?

In my setting, every humanoid creature in our worlds mythology is part of a different species that branched off from humans millions of years ago. I'm trying to devise a way to prevent crossbreeding so I can realistically have multiple races without cross breeding and assimilation.

Question: In order to prevent the humanoids from mating with each other and creating viable offspring, what conditions can I create to prevent interspecies mating?

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Preventing inter-species breeding in humanoids?

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