A poison that only works if you know it is there

In the book He Drank and Saw the Spider, a poison is talked about in a metaphorical way: A person can be poisoned by putting a specific kind of spider into their cup, but the poison only works if you drink and then see the spider. If you don't see the spider, then nothing will happen.

The book used it as a metaphor, but how could a poison like that exist, where it only works if you know you've been poisoned?

The book is fantasy, with magic being a thing, but it is very rare in the universe.

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A poison that only works if you know it is there

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