Is there an impact event scenario where vegetation could survive on the surface but humanity would not?

I am working on a scenario that begins with an impact event. I have multiple questions, but I'll start with the catalyst for this world.

Is there a type of impact event that would not be a global killer, but basically poison the air, forcing humanity to live in shelters for a few years, while allowing vegetation to (at least some degree) survive?

The World: The world I am creating forces humanity into shelters, where they can resurface in a few years in protective gear, leaving behind a, still vegetated, but drought-like surface. I'd like a realistic scenario to allow for this, ideally stemming from an impact event.

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Is there an impact event scenario where vegetation could survive on the surface but humanity would not?

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