Are there any outstanding factors that would prevent marsupials from evolving civilization?

Humans are derived from arboreal shrew-like animals that survived the cataclysm which wiped out the larger dinosaurs. As far as I am aware this series of events is entirely the result of chance. Would being marsupials have adversely affected the development of heuristics, tool use, civilization, etc?

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Are there any outstanding factors that would prevent marsupials from evolving civilization?

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