Gravity Difference and its Impact on Humans

Is there an equation between the factor of Earth's gravity (the moon is (1/6)G) and how long a person can reasonably stay in that environment before returning to Earth would cause serious issues? Obviously humans would survive easier on a planet with say 7/8 of Earth's gravity or 10/9, etc, than something further on the number line like 1/8 or 5/3, which led me to my question.

Serious issues in the sense that they would need a cane to walk, or oxygen to breathe, a wheelchair, etc. Something that they used to be able to do on their own would need supplemental assistance because of the lack (or augmentation!) of gravity in the environment they spent time in. Is there a way to know the reasonable estimate before that happens?

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Gravity Difference and its Impact on Humans

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