Is it possible for humanity to completely annihilate itself?

Is it possible for humanity to completely annihilate itself? By that I mean there cannot be one survivor left and the annihilation must be caused by humanity itself with current technology (no crazy AI killing everyone) and not by natural disasters (no giant meteorite).

Nuclear war: There will still be some survivors and some place on earth will have tolerable radiation levels.

Genetically engineered killer pathogen (virus/bacteria/parasite): Because our gene pool is so diversified, some people will naturally be immune to it, some people in remote area won't catch the pathogen.

Desertification/Global warming: Some areas near the poles will still be fertile.

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Is it possible for humanity to completely annihilate itself?

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