Could a new auto-immune disease develop because humans live in too sterile of an environment?

In the future, AI systems sanitize humans as they walk through doorways. Home surfaces self-sanitize. Food is mostly 3D printed from cleaned particles, including Vitamin K and possibly some probiotics to aid digestion. Humans are not forbidden from leaving the protected city, but few do. There's minor barrier crossing of people, but sterilizing agents penetrate clothing and clean them as they re-enter the city.

Could this spur the creation of a new auto-immune disease where the body attacks itself for lack of anything else to fight?

I want to position the environment as the cause of the new disease. Am I missing a big plot hole in this idea?

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Could a new auto-immune disease develop because humans live in too sterile of an environment?

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