Ways to make an alien viral plague scientifically hard?

Aside from resorting to a grey goo-ish nanoplague that kills indiscriminately regardless of biochemistry, how might an alien virus, bacteria or other pathogen still be dangerous to humans? Could a disease with incompatible biochemistry still cause damage to the human body if a person is exposed to it, or would the lack of appropriate nutrients make it impossible to breed inside a human host and thus cause any intentional or unintentional harm to it?

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Ways to make an alien viral plague scientifically hard?

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