How to negate the effects of long-term close relative inbreeding in a ruling dynasty?

This is inspired by GRRM's A Song of Ice and Fire, where for millennia House Targaryen wed brother to sister at all possible opportunities, and Aunt to nephew, Uncle to niece, and cousin to cousin where that was not possible. As a result, the family had a propensity for madness, and often times children born of such unions would be stillborn, or be born horribly deformed. By the end of their reign, 5 out of 8 children born to them were stillborn.

They only out-bred a few times, and notably before the Mad King triggered the collapse of their dynasty, three generations of complete out-breeding with people totally unrelated happened. This was extremely rare. Should I expect this, or is there a way to stop the genetic disorders associated with this strong inbreeding?

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How to negate the effects of long-term close relative inbreeding in a ruling dynasty?

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