How do I isolate a city?

Is it possible, the world being as it is for a city to be isolated completely from the world? Assume technological advancements to be the same as they are today.

Would such a scenario be feasible? Can a city be effectively besieged for an indefinite amount of time in such a way that no one can enter or exit? What effect would this have on the people living in such a city?

Quick Edit: Thank you for all the amazing answers. Just want to clarify, this is being done to them, they aren't cooperating

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Communities

How do I isolate a city?

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