What is a realistic plague that could have wiped out the population of an island?

Running a Steampunk campaign with some friends. The idea is that a massive a destructive plague wiped out the population of an island that was really technologically advanced. The plague needs to somehow still be around, as explorers and such have not successfully returned from the isle. The implication is that the plague was caused by the people on the island reached too far into the realm of science and technology with devastating consequences. What could have caused the plague? How could you combat it? What is the most interesting side-effect you could imagine for a plague?

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What is a realistic plague that could have wiped out the population of an island?

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