How can I make humans not negatively affected by radiation?

My people are traveling in a generation ship. For some reason they can't make the ship radiation-proof. Their solution: genetically modify their descendants to be radiation proof. How could one modify a cell to resist radiation? Is it plausible to modify our genetic structure to be radiation-proof?

Assume they have a level of tech about fifty to a hundred years ahead of our current level.

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How can I make humans not negatively affected by radiation?

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