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Biology-centric civilization vs AI-based civilization

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I wonder if it possible for human civilization to evolve into two different civilizations.

One is controlled by artificial intelligence (or by uploaded human minds) and the other is biology-based with all kinds of imaginable biological advances such as interconnected brains, bio-machines, specialized organisms, advanced biological soldiers both land-based, flying and swimming types, controlled insect-like nano-organisms, on-the-fly mutations in necessity, multi-cloning and perfectly looking "people" with hyper-abilities and regeneration etc.

The both civilizations think of themselves as the true cultural continuation of humanity, admire human history and the like.

Both sides conduct a lot of research.

I wonder how such distinction would be preserved if the civilizations came into contact. How it is possible to avoid intermix of the technologies? Can they co-exist on the same planet? How their war would look like? Can advanced bio-technology be developed without traditional computers (or after refusing traditional computers), totally relying on the artificially-grown huge brains?

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This post was sourced from https://worldbuilding.stackexchange.com/q/8498. It is licensed under CC BY-SA 3.0.

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