When does gravity become too much for humanoids?

Supposing you took Earth or a planet like it and doubled its mass, the gravity would obviously increase in whatever proportion to that.

As a result, humans as we know them would be ... thicker, (I guess?) to support the additional gravity.

At what order of magnitude of gravity (or its relative size to Earth) would it become impossible to support a humanoid(ish) life form? That is, the body can only adapt to gravity to a certain degree before it is way too overwhelming to support life.

I am looking to get an idea of how much gravity that would take, and which crippling physiological factor would be the first to make humanoid life impossible to live.

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When does gravity become too much for humanoids?

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