Is it possible to genetically modify a being after birth?

In many stories we hear about people whose genetic structure is modified after they're born (Spider-man, The Fantastic 4 and practically any other superhero you care to mention). However current science focuses very much on modifying the DNA at the earliest stages of life (if not before) and allowing the embryo to develop.

Is it possible that genetic changes could be made to an adult human? If so what techniques would be used (the only method I can imagine is viral?).

What would a person undergoing this treatment feel like? Would it feel like the flu? Would it feel like they're burning? Would their body go numb?

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Is it possible to genetically modify a being after birth?

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