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Comments on Plausibility of "multi-type transmissible animal cell tumor" to form more complex structures.

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Plausibility of "multi-type transmissible animal cell tumor" to form more complex structures.

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There's apparently a type of transmissible cancer that came from new world dogs thousands of years ago, the Canine transmissible venereal tumor. As I understand, this self replicating surviving cancer has DNA from new world dogs no longer found in the current canine population. It's its own "thing", not from a virus, radiation, or chemical phenomena.

I would like to postulate the possibility of more than just one type of cell metastasizing in a animal. Would it be possible for multiple types of "cancer" cells (or at least host foreign animal cells) to work in unison to create new structures? For example, extending a cardio vascular system, or nervous system through out the tumor, or, at the most far fetched side of things, a new appendage, like a cancerous "ear" formation (like a bunch of ears starting to grow in an area on the dog/animal due to this foreign cell "infection"?).

Even if this couldn't happen in general, would this be feasible with compatible immune systems, such as those found with inbred animals?

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Canina‭ wrote over 4 years ago

For those wishing to learn more about CTVT, check out the scientific article (open access) at https://science.sciencemag.org/content/361/6397/81. There are summaries at least at https://science.sciencemag.org/content/361/6397/27 and https://www.nature.com/articles/d41586-018-05645-5.

Jordan‭ wrote almost 4 years ago

If a stem cell goes cancerous it doesn't seem crazy that the host might grow lots of arms or ears. I'm not sure how to manage the transmission of only the stem cell, and not daughters. And, in this scenario, there is no real distributed cooperation among the cancer cells... most instructions still come from the stem cell command center.