That is what they do at LHC and similar facilities
I am serious: a collider is in essence a huge random number generator. The research consists of looking at the random data you get out from it and try to spot where the randomness is skewed.
EDIT: I suppose your question is this: your character has a random seed that is supposed to be entirely random, based on baryon symmetry. And then the character feeds that into a pseudo random number generator and expects to get a random result.... but does not.
Well... that could work. Pseudo random number generators work by mangling the seed in such a way that you can never go back. A PRNG essentially obfuscates the input beyond recognition. If your character "” by extraordinary luck "” stumbles upon a PRNG algorithm that is somehow related to whatever PRNG The Big Simulation™ is using to simulate our universe, then yes... there could be unexpected order in the output from your character's PRNG.
Do note that this is far beyond our present understanding of mathematics. We do not know how to reverse hash algorithms. That is not to say it cannot be done, that there exists some kind of anti-hash. But if that is what The Big Simulation™ uses to produce its randomness, then that would work as a plot element. If someone uses a random element from nature as the seed for a random number generator, and somehow gets a skewed result, then he will know something very strange is up.
For correlation he could use some other random process for his PRNG algorithm. If he gets a random result from that, and only gets a skewed result from a specific random seed, then that would be a very clear hint that the universe is far more algorithmic than we have assumed so far, and that it might even be a gigantic digital simulation.