Is this an appropriate manned interstellar mission profile?

My idea was to use 2 stages for an interstellar spacecraft (particularly the Orion Drive) and use it in a way similar to Project: Daedalus. Phase 1 would involve accelerating to cruising speed following assembly in orbit, and that cruising speed is 0.04 c, which will then slow down as we approach the Wolf 1061c (the target planet) system. There is a problem: is this appropriate and if not, what are some issues I need to concern myself with?

EDIT: I am also going to provide a link for those of you who do not know what "mission profile" is by giving you a hands-on interplanetary or orbital example. Mission Profile Description, Definition and Example

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Is this an appropriate manned interstellar mission profile?

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