Energy gain/loss of using synthesized antimatter as a fuel?

Setting aside concerns of containment for now; how much energy would it take to create antimatter? And how much of it would we get back using it as a fuel in a matter-antimatter reactor?

What I'm worried about is that the amount of energy you put into making antimatter is less than the amount of energy you get back during annihilation. I was also looking to get a general idea of how much of a gain/loss there would be.

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Energy gain/loss of using synthesized antimatter as a fuel?

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